Process Development Engineer - Early Phase Peptide/Oligonucleotide, Indianapolis

Process Development Engineer - Early Phase Peptide/Oligonucleotide

New Yesterday

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Job Description

Synthetic Molecule Design and Development (SMDD) is involved in key activities for the development of synthetic active pharmaceutical ingredients from pre-clinical phases through commercialization of drug substances and drug products. Our scientists and engineers develop key technical and business solutions across the portfolio using their deep technical expertise to accelerate testing of the clinical hypothesis and overall drug development. SMDD delivers on these responsibilities by recognizing diverse talent and cultures are necessary to bring the next generation of life changing medicines to patients.

SMDD has an exciting opportunity for an innovative chemical engineer to join our engineering group within its early phase TIDES (peptide and oligonucleotide) team. The engineer will join a highly dynamic and cross-functional team developing synthetic peptide processes and facilitate technology transfer/scale up to pilot plant. They will be part of a diverse team of chemical engineers, synthetic chemists, formulation scientists and analytical chemists, working to deliver product and process understanding across various TIDES platforms.

The early phase TIDES team is responsible for developing synthesis processes to rapidly deliver pilot toxicology study materials for next generation therapeutic peptides. The engineer will gain experience with synthetic molecule unit operation design, utilizing data-rich experimentation techniques to yield innovative solutions to TIDES synthesis challenges. Join our team in advancing peptide process development and delivering life-changing medicines to patients worldwide.

Position Responsibilities

Generate process design and unit operation knowledge based on engineering principles for small molecules, peptides, oligonucleotides, and other emerging therapeutic modalities.
Ensure successful scale-up of processes through fundamental engineering principles and equipment knowledge.
Design and execute laboratory experiments related to solid phase and liquid phase peptide and oligonucleotide synthesis, and downstream purification and isolation.
Develop drug substance and manufacturing technologies.
Engage in generating creative solutions for improving existing processes and the creation of novel ones.
Transfer process technical information to internal pilot plant. Provide technical oversight for pilot scale GMP manufacturing activities.
Author and maintain documentation such as laboratory notebooks and technical reports.
Apply fundamental engineering and business principles to design and characterize synthetic processes. Use numerical engineering modeling tools to characterize reaction kinetics, reaction mechanisms, and process separations.
Design effective and efficient process and equipment flow strategies, ensuring equipment is selected which is suitable and appropriate for its intended use, given the specific needs of the process.
Stay informed about new technology and best practices. Propose, justify, evaluate, and implement new equipment, processing techniques, and technologies.
Utilize technology to improve safety, quality, and productivity, both in development and manufacturing.
Publish and share original research externally through peer-reviewed articles and conferences.

Minimum Qualifications:

B.S (0-12 years industry experience). or M.S. (0-9 years industry experience) in chemical engineering or closely related field.

Additional Skills/Preferences

Strong technical skills in synthetic organic chemistry with experience as a hands-on technical contributor in a laboratory environment.
Prior experience of solid phase and/or liquid phase synthetic peptide and oligonucleotide process is preferred but not required.
Demonstrated problem solving skills.
Strong verbal and written communication skills and ability to collaborate in a team environment.
Ability to prioritize multiple activities and handle ambiguity.

Additional Information

Travel: 0 to 10%.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$97,500 - $143,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

Apply

Location:: Indianapolis
Job Type:: FullTime

Start a New Search